FACTORS AFFECTING PLASMA LEVELS OF LIGNOCAINE AND PRILOCAINE
نویسندگان
چکیده
منابع مشابه
Factors affecting plasma levels of lignocaine and prilocaine.
Plasma levels of local anaesthetics following their injection are affected by many factors. Serial plasma levels following injection of lignocaine and prilocaine at various rates in over 500 patients have been measured and this has allowed some of these factors to be assessed and quantified. The vascularity of the site of injection causes major differences in the maximum plasma level. Prilocain...
متن کاملBrit. J. Anaesth. (1972), 44,1040 FACTORS AFFECTING PLASMA LEVELS OF LIGNOCAINE AND PRILOCAINE
Plasma levels of local anaesthetics following their injection are affected by many factors. Serial plasma levels following injection of lignocaine and prilocaine at various rates in over 500 patients have been measured and this has allowed some of these factors to be assessed and quantified. The vascularity of the site of injection causes major differences in the maximum plasma level. Prilocain...
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Intravenous lignocaine (1 mg./kg. body weight) was found to produce insignificant haemodynamic changes, and in particular no reduction in myocardial contractility. A rate of 2 mg./minute infused intravenously is suggested for therapeutic purposes.In anaesthetized dogs an infusion of 13.5 mg./minute caused moderate haemodynamic depression and a maximum plasma level of 7 mug./ml. Massive injectio...
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refer patients for unpleasant investigations was a factor, as was the patients' age, particularly if they were over 75 or under 40.5 We found that the mean delay from the onset of symptoms to surgical treatment was 19 weeks for left sided carcinomas and 29 weeks for right sided carcinomas. This is an improvement on the 38 and 31 weeks, respectively, of 1979.4 This may be due to increased recogn...
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In a double-blind, double-dummy study, the efficacy of topical 5% EMLA cream was compared with that of lignocaine infiltration in alleviating the pain of arterial cannulation. Forty unpremedicated adults were allocated randomly to four groups to receive EMLA cream alone, EMLA and 0.9% saline infiltration, EMLA and 1% lignocaine infiltration or placebo cream and 1% lignocaine infiltration. Follo...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1972
ISSN: 0007-0912
DOI: 10.1093/bja/44.10.1040